Cytogenetics

The SydPath Cytogenetics/FISH Laboratory offers a comprehensive service for the karyotyping and fluorescence in situ hybridisation (FISH) testing of specimens for the diagnosis and follow-up of patients with haematological and solid tumour malignancies.

The laboratory is the only NATA-accredited laboratory in NSW to offer a solely cancer-focused service.

The service encompasses the:

  • Karyotypic analysis of bone marrow, trephine and unstimulated peripheral blood specimens for the diagnosis of myeloid malignancies and lymphoproliferative disorders.
  • Karyotypic analysis of lymph node and solid tumour biopsies for the diagnosis of lymphomas and solid tumours.
  • Quantitative PCR analysis of blood specimens for transcript detection in p210 transcript positive chronic myeloid leukaemia (CML) at diagnosis and follow-up. Results are available within 24 hours of specimen receipt.
  • FISH analysis of cytogenetic fixed cell suspensions, prepared from bone marrow, trephine and unstimulated peripheral blood specimens for the detection of a comprehensive range of genetic rearrangements diagnostic for a wide range of myeloid malignancies and lymphoproliferative disorders. Urgent overnight testing can be arranged.
  • FISH analysis of CD138-selected cells from bone marrow specimens for prognostication in multiple myeloma (MM).
  • FISH analysis of oligo/IL2-stimulated culture preparations for prognostication in chronic lymphocytic leukaemia (CLL).
  • FISH analysis for XX/XY chimerism post sex-mismatched allogeneic transplantation.
  • FISH analysis of formalin-fixed paraffin-embedded (FFPE) tissue and lymph node/solid tumour touch imprints for the detection and prognostication of a comprehensive range of genetic rearrangements in lymphomas/solid tumours.
  • Consultation regarding appropriate specimen collection, probe selection and result interpretation for these karyotypic/FISH analyses.

Contact Details:

Ms Mary Suter
BSc,MA,MPH,FHGSA (Cytogenetics)
Senior Scientist
T: (02) 8382 9155

Dr Robyn Lukeis
BSc(Hons),PhD(Medicine),FHGSA(Cytogenetics),FFSc(RCPA)
Senior Scientist
T: (02) 8382 9154

Laboratory
T: (02) 8382 9153
F: (02) 8382 2493

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